Dr. Spencer Nadolsky, Dr. Karl, and chief science officer Dr. Grant Tinsley sit down with Dr. Steven Heymsfield, physician at the Pennington Biomedical Research Center and lead author on the BELIEVE trial, to break down what happens when you combine bimagrumab with semaglutide and why over 90 percent of weight lost in the combination group was pure fat. Dr. Heymsfield has published over 600 peer reviewed articles and is widely considered one of the foremost body composition researchers in the world, and Grant Tinsley credits him as a foundational influence on his own work in the field. In this episode they cover what bimagrumab actually is and how blocking the activin receptor causes muscle to grow, the origin story of the drug from Novartis to Versanus to Lilly and why sarcopenia research accidentally opened the door to obesity treatment, the nine group trial design and what it really boils down to, why the bimagrumab only group lost 7 percent of their weight entirely as fat without reducing food intake, the LDL cholesterol finding that has everyone talking and whether it actually matters, what happens to muscle and weight when you come off both drugs, why visceral adipose tissue practically disappeared in the antibody treated groups, the functional outcomes data including grip strength and physical activity scales, whether a subcutaneous version is coming, and what the future of this drug class looks like now that Lilly has deprioritized it. The Docs Who Lift podcast distills and simplifies the complexities of exercise, medicine, and weight loss. Subscribe so you never miss an episode. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Dr. Spencer and Karl Nadolsky bring on Dr. Alyssa Olenick, exercise physiologist and postdoctoral researcher in menopause and metabolism, to cut through the noise on one of the most misrepresented topics in women's health. Dr. Olenick holds a PhD in exercise physiology, completed postdoctoral training focused on menopause and body composition, and is the founder of the Liss Method, a hybrid training program combining strength and endurance. She has been doing women-specific and sex-difference research since her master's degree and is one of the sharper voices pushing back on the wave of pseudoscience targeting women in the fitness space. In this episode they cover what actually changes in body composition during the menopausal transition and what does not, why fitness status matters more than menstrual cycle phase or contraceptive use, how the fitness industry profits from pinkifying advice that was never women-specific to begin with, the truth about rep ranges and why effort matters more than the number, cortisol myths and why the adaptive stress response to exercise is not your enemy, and how to approach training adjustments during perimenopause without overcorrecting into low intensity fear-based programming. No pseudoscience. No pink packets. Just the research.Follow Dr. Olenick Here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Takeaways: Creatine is a naturally occurring compound that helps regenerate ATP, the energy currency of the cell. Supplementing with creatine can enhance performance in high-intensity exercise but may not be beneficial for endurance activities. The majority of creatine is stored in muscle, and supplementation can help fill those stores for better energy availability. Creatine monohydrate is the most studied and effective form of creatine, and it's also the cheapest. There is no need to cycle creatine; continuous use is safe and effective. Creatine supplementation is generally safe, but individuals should inform their healthcare providers about its use. The benefits of creatine are most pronounced in individuals engaging in high-intensity exercise. Creatine does not directly build muscle; it requires exercise to be effective. There is a misconception that creatine is harmful to the kidneys; it is safe for healthy individuals. Creatine supplementation may have potential cognitive benefits, but more research is needed.Follow Dr. Lauren     Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Takeaways:The 11-Minute Rule: Why blue light isn't the villain you think it is. The Melatonin Mistake: Why "less is more" (and the exact dosage for success). Trackers vs. Reality: When to throw away your Apple Watch or Oura Ring. The Bedrock Principle: Why sleep is the lead domino for fat loss and metabolic health. Sex & Sleep: The surprising biological difference in how men and women recover. Tap Here to follow ShelbyShelbys Book Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Get The Lucky Egg Book HereTakeaways:Dr. Lucky Sekhon is a reproductive endocrinologist and author of 'The Lucky Egg'.The pathway to reproductive endocrinology involves extensive training in OB-GYN and specialized fellowship.Social media became a tool for Dr. Sekhon to combat misinformation during the pandemic.Common myths in fertility include the idea that one can reverse the biological clock.Understanding the fertility knowledge gap is crucial for patients seeking help.Insulin resistance plays a significant role in fertility issues, especially in women with PCOS.Fertility treatments should be evidence-based and tailored to individual needs.GLP-1 medications can help regulate menstrual cycles and improve fertility outcomes.Endometriosis can significantly impact fertility and requires tailored treatment approaches.The importance of patient education in navigating fertility treatments cannot be overstated.   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

TakeawaysExcellence is not a standard but a process of becoming.Involved engagement means caring deeply about what you do.The pursuit of excellence shapes you into a better person.Consistency is key to achieving long-term goals.It's important to align your pursuits with your values.Youth sports can be beneficial but also harmful if not approached correctly.Weight loss should shift from a focus on numbers to health and well-being.Building a diverse identity can help prevent burnout in athletes.The transition out of sports can be challenging due to identity loss.Enjoying the process is more fulfilling than the end goal.Tap or Click Here to Buy Brads Book Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Key Episode TakeawaysOral Wegovy is real, but it’s not “just a pill version of the shot.” Absorption rules, dosing schedules, and patient selection matter a lot more than most headlines suggest.Switching from injections to oral GLP-1s requires a plan. The transition isn’t one-size-fits-all, and dose timing, GI tolerance, and expectations need to be managed carefully.Weight regain after stopping GLP-1s is common, but not universal. SURMOUNT-4 data shows large variability, reinforcing that biology, not willpower, drives outcomes.Maintenance matters as much as weight loss. Some patients need continued therapy at lower doses, while others may maintain with lifestyle plus strategic medication use.Stopping abruptly is usually the worst approach. Gradual transitions and realistic long-term strategies reduce rebound weight gain.GLP-1s are chronic disease tools, not short-term fixes. Treating obesity like hypertension or diabetes leads to better outcomes and fewer surprises. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Takeaways:Dietary guidelines have evolved since the 1980s.The food pyramid was introduced in 1992 and has influenced public perception.New dietary guidelines emphasize healthy fats but retain some old recommendations.There are contradictions in the new guidelines regarding saturated fat and protein intake.The definition of processed foods remains vague and controversial.The guidelines are intended for healthcare professionals, not consumers.Public policy needs to align with dietary guidelines for effective implementation.The emphasis on real food is not a new concept in dietary guidelines.There is skepticism about whether the new guidelines will lead to meaningful changes in public health.The conversation around dietary guidelines is often politically charged.Follow Kevin: Tap Here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Takeaways:Cortisol is essential for various bodily functions, especially during stress.Adrenal glands have a circadian rhythm that affects cortisol production.Cushing's syndrome can result from excess cortisol and has specific symptoms.Diagnosis of adrenal disorders requires careful testing and consideration of symptoms.Mild autonomous cortisol secretion can complicate diabetes management.The Catalyst trial explored the effects of cortisol antagonism on diabetes.Future research may focus on selective glucocorticoid receptor modulators.Woolly mammoth studies provide insights into historical testosterone levels.Understanding adrenal health is crucial for effective patient care.Endocrinologists must navigate the complexities of hormone testing and treatment.   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Takeaways:Slimmer's Paralysis is a recognized condition.Ethical boundaries are crucial in patient relationships.Medical professionals must maintain professionalism at all times.Humor can sometimes arise in serious discussions.Patient stories should always be handled with care.The importance of clear communication in medical settings.Understanding patient experiences is vital for effective care.Ethics in medicine is a complex and nuanced topic.Medical discussions can lead to unexpected topics.Maintaining a professional demeanor is essential.   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Takeaways:Drug transfer during lactation is complex and challenging.Semaglutide was not detected in women taking any dose.Low amounts of tears epitide were found in milk.Tissue damage can affect drug absorption.Mastitis and engorgement complicate the lactation process.Injections are necessary for effective drug delivery.The analogy of an elephant illustrates the difficulty of drug transfer.Detection of drugs in milk is a critical concern for breastfeeding mothers.Understanding turnover is essential in lactation studies.The implications of drug transfer on women's health are significant.Infant Risk Center Link  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Takeaways:Behavior change is a complex process that requires understanding motivation and discipline.Motivation is not just a feeling; it's a psychological skill that can be developed.Many common phrases about behavior change are misleading and oversimplified.Exercise should be viewed as a choice rather than a habit that becomes automatic.Self-efficacy is crucial for successful behavior change and can be built through mastery experiences.Future self thinking can help individuals align their actions with their long-term goals.It's important to lower barriers to entry for new behaviors to increase adherence.Modeling healthy behaviors is essential for influencing children and adolescents.The psychological definition of a habit differs from the colloquial use of the term.Resources and support systems are vital for individuals looking to change their behaviors.Follow Dr. Nordin Herehttps://bodybrainalliance.com/ Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Testosterone therapy can improve libido in postmenopausal women.Sexual dysfunction in women is complex and multifactorial.Low sexual desire is only considered a disorder if it causes distress.Psychosocial factors play a significant role in sexual health.Testosterone levels do not change significantly at menopause.The placebo effect can significantly influence treatment outcomes.Individualized care is crucial in managing sexual dysfunction.Dosing for testosterone therapy should be carefully monitored.Current medications for low libido have modest benefits.Evidence for testosterone therapy in premenopausal women is still emerging.Tap to Follow Dr.Susan Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Show Notes:In this episode of Docs Who Lift, the Nadolsky brothers welcome back Dr. Sean Wharton, clinical trialist and one of the leading researchers behind the next generation of oral GLP-1 medications. Together, they break down:The OASIS-4 trial results on 25mg oral semaglutide and how it stacks up to injectable WegovyHow orforglipron, Eli Lilly’s new small-molecule GLP-1, differs from peptide-based drugsWhy these new therapies could make weight management more accessible and affordableThe fascinating pharmacology behind “snack molecules” and small-molecule receptor agonistsCommon misconceptions about bioavailability, dosing, and side effectsThe potential role of oral GLP-1s for patients with mild obesity or cardiometabolic diseaseWhether you’re a clinician, researcher, or patient curious about the future of obesity medicine, this conversation offers a clear look at how science is shifting toward needle-free solutions.Oasis 1 Trial LinkOasis 4 Trial LinkAttain 1 Trial Link Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of Docs Who Lift, the Nadolsky brothers dive deep into the newly released American Association of Clinical Endocrinology (ACE) Algorithm for Obesity Care led by Dr. Karl himself. They explore:Why ACE moved away from a BMI-only approach to a person-centered, complication-centric modelThe new staging framework (ABCD) that helps individualize treatment intensityHow to interpret “clinical” vs “preclinical” obesity under the new modelUpdated targets for clinically meaningful weight loss (5%, 10%, 15% tiers)The emphasis on resistance training, sleep, and behavioral health alongside nutritionPractical guidance for selecting anti-obesity medications and identifying the right therapy for each patientWhether you’re a clinician, health professional, or patient trying to understand modern obesity care, this episode breaks it all down in a practical, real-world way without the jargon.Youtube Video to follow along the graphic mentioned Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

TakeawaysThe book aims to dispel myths surrounding the Biggest Loser study.Miscommunication in media has led to public confusion about metabolism.Metabolic adaptation is a response to weight loss, not a determinant of it.Cultural factors significantly influence eating habits and food choices.The food environment plays a crucial role in dietary behaviors.Bipartisan support is necessary for effective food policy changes.Understanding metabolism requires a nuanced approach beyond just calories.The relationship between exercise and metabolism is complex and not fully understood.Appetite signals are a major factor in weight regain after dieting.Education about nutrition science is essential for public understanding.Julia Belluz X/TwitterKevin Hall X/TwitterPurchase Their Book Here  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Takeaways Menopausal women often prioritize weight gain concerns over other symptoms.The study observed an association between hormone therapy and weight loss with GLP-1 medications.Retrospective studies have limitations but can provide valuable insights.Future research should focus on randomized controlled trials to confirm findings.The relationship between estrogen and GLP-1 signaling needs further exploration.Funding for research can be challenging, especially for early career investigators.Collaboration between different specialties is crucial for comprehensive patient care.The media often misrepresents research findings, leading to misconceptions.Individualized treatment plans are essential for menopausal women.There is a need for more awareness about the effects of menopause on health.Research Links:Weight loss response to semaglutide in postmenopausal women with and without hormone therapy useCombination of obesity medication tirzepatide and menopause hormone therapy fuels weight loss   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

We covered:Fasted trainingProtein timingand many more fitness topics!Hear Dr. Lauren Colenso-Semple and Dr. Stacy Sims discuss outcomes versus mechanisms and much moreTap Here for Dr Stacy Sims ReferencesTap Here for Dr. Colenso-Semples ReferencesDr. LCS InstagramDr. SS Instagram  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

TakeawaysThe podcast features Dr. Grant Tinsley, a body composition expert.The discussion revolves around a case series on body composition effects.GLP-1 receptor agonists are a focus of the research.The importance of resistance training in weight loss is emphasized.Patient case studies provide insights into individual experiences.The first patient lost a significant amount of fat mass while preserving lean mass.The second patient achieved remarkable body composition changes in a short time.The third patient showed positive changes over a longer duration.The need for more randomized trials is highlighted.The conversation underscores the role of exercise and nutrition in weight management.Tap or Click here to see more from Dr. GrantTap here for scientific references in this episode. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

TakeawaysDirect-to-consumer lab testing is on the rise, with significant marketing efforts behind it.Many patients feel brushed off by traditional healthcare providers, leading them to seek alternative testing options.Communication between patients and healthcare providers is often inadequate, contributing to misunderstandings about health.Over-testing can lead to unnecessary anxiety and misinterpretation of results.Fitness influencers often promote lab testing without proper medical training, which can be harmful.There is a need for ethical practices in lab testing and patient care.Patients should be cautious of companies that upsell supplements based on lab results.The healthcare system often fails to provide adequate time for patient concerns to be addressed.Understanding lab results requires skilled interpretation, which is often lacking in direct-to-consumer models.A collaborative approach among healthcare professionals is necessary to improve patient outcomes.Click to join Dr. Spencer's online clinic if you need help with this  Click here to check out Barbell Medicine Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of the Dr. Lift podcast, hosts Dr. Spencer Nadolsky and Dr. Karl discuss the recent changes in obesity medication coverage, particularly focusing on the CVS Caremark decision to drop ZEPBound from their formulary in favor of Wegovi. They explore the implications of this decision for patients and providers, the role of pharmacy benefit managers (PBMs) in healthcare, and the ongoing advocacy efforts to ensure access to effective obesity treatments. The conversation highlights the complexities of insurance coverage, the need for patient-centered care, and the importance of making medications more affordable.- The recent changes in obesity medication coverage have raised concerns among providers and patients.- CVS Caremark's decision to drop ZEPBound has sparked a petition advocating for better access to medications.- Pharmacy Benefit Managers (PBMs) play a significant role in determining medication coverage and costs.- There is a need for more nuanced insurance policies that consider patient needs and clinical severity.- Advocacy efforts are crucial in reversing negative trends in medication coverage.- Patients often face challenges with prior authorization processes when switching medications.- The cost of obesity medications is a significant barrier to access for many patients.- Insurance companies are increasingly dropping coverage for anti-obesity medications, impacting patient care.- The conversation emphasizes the importance of patient-centered care in obesity treatment.- There is a call for making obesity medications more affordable and accessible to patients.https://www.change.org/p/stop-cvs-caremark-s-zepbound-ban-restore-coverage-of-the-superior-obesity-medicationClick to join Dr. Spencer's online clinic if you need help with this  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of the Dr. Lift podcast, hosts Dr. Spencer Nadolsky and Dr. Karl discuss the Surpass CVOT trial, which evaluates the cardiovascular outcomes of Monjaro compared to Dulaglutide (Trulicity). They delve into the significance of the trial, the implications of the results, and the potential benefits of Monjaro for patients with type 2 diabetes and cardiovascular risks. The conversation highlights the importance of understanding cardiovascular outcome trials and the evolving landscape of diabetes medications.Takeaways: The Surpass CVOT trial compares Mounjaro to Dulaglutide.Dulaglutide has shown cardiovascular benefits in previous trials.The trial results indicate Monjaro is at least not inferior to Dulaglutide.There is a trend towards better cardiovascular outcomes with Mounjaro.Weight loss and glycemic control are significant benefits of Mounjaro.The trial did not include a placebo, but used a putative analysis.The results are reassuring for patients at high cardiovascular risk.The conversation emphasizes the importance of comprehensive treatment for metabolic diseases.The hosts express enthusiasm for the potential of Mounjaro.Future discussions will delve deeper into the trial's findings.       Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

How the STEP-UP trial came to life,  and what made the 7.2mg dose possibleWhat the data actually says about weight loss and side effects at higher dosesWhy trial design, pharmacokinetics, and estimands matter more than you thinkWhat’s coming next in obesity meds: duals, triples, and even antagonistsThe real talk on intermittent fasting, access issues, and preaching vs. scienceSign up for Dr. Spencer''s Clinic Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

TakeawaysThe study examines the overlap between clinical and anthropometric obesity.Anthropometric measures include waist circumference, waist-to-hip ratio, and BMI.Challenges exist in applying the Lancet Commission's definitions in clinical practice.Metabolically healthy obesity is a debated topic in obesity research.The study highlights the importance of data from the All of Us Research Program.There is a significant prevalence of preclinical obesity in individuals with normal BMI.The classification of obesity may need to shift focus towards overweight individuals.The study's findings suggest a need for more nuanced definitions of obesity-related diseases.Future research will explore the transition from preclinical to clinical obesity.The conversation emphasizes the importance of real-world data in understanding obesity.Click here to see the studyFollow Dr. Yao on X hereFollow Dr. Blaha on X here Click here to join Dr. Spencer's online clinic   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Learn what age-related macular degeneration (AMD) isWhat causes AMDThe types of AMDThe update on NAION - listen to last year's podcast all about itWhy we aren't too concernedClick here to join Dr. Spencer's online clinic VineyardClick to read the JAMA AMD articleClick to read the Ophthalmology journal AMD article Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Menopausal hormonal therapy should not be a blanket recommendation for everyone going through menopauseWeight management in women is influenced by hormonal changes throughout life stages.Retrospective analyses can provide insights but have limitations.The wellness industry often oversimplifies complex medical issues.Hormonal replacement therapy may have subtle benefits for weight management.Confounding factors like SSRIs can complicate weight loss efforts.A holistic approach is essential for managing women's health during menopause.Education and awareness are crucial for women navigating menopause.Future research should focus on randomized controlled trials for better clarity.Understanding individual patient experiences is key to effective treatment.Click here to see her studyClick here to follow Dr. Tchang on XClick here to join Dr. Spencer's clinic Vineyard  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Dr. Grant Tinsley joins the discussion as the body composition expert.Myostatin is a key regulator of muscle growth.Wendy Whippete the most jacked muscled up dogThe concern of GLP-1 receptor agonists and muscle mass loss.Overview of Courage trial looking at semaglutide and trevogrumab and lean mass lossUpcoming Believe trial coming out (bimagrumab and semaglutide)Exercise remains crucial for muscle health and function.MRI data from SURPASS MRI provides new insights into muscle volume changes.The combination of medications may have varying effects on muscle mass.Caution is advised regarding the long-term effects of new drugs.Clinical benefits of medications often outweigh concerns about muscle loss.Future research will explore the synergy between exercise and medication.Other docs who lift podcasts with Dr. Grant:Tirzepatide muscle lossLean mass loss and GLP-1 meds Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Takeaways:The MAHA report aims to address public health issues but lacks actionable policies.Historical context is crucial for understanding current dietary guidelines.Funding for nutrition research has been inadequate, impacting the quality of data.Public perception of nutrition often outpaces scientific evidence.The evolution of dietary guidelines reflects political and social influences.There is a need for more rigorous nutrition science to inform policy.The dietary guidelines have not significantly improved population health metrics.Political will is essential for implementing effective nutrition policies.Nutrition science faces challenges in funding and research infrastructure.The MAHA report's recommendations may be more performative than substantive. Food policy changes are often superficial and ineffective.There is a significant disconnect between policy and actual health outcomes.Nutrition science is underfunded and lacks high-quality research.Misinformation in nutrition can lead to harmful public health outcomes.The focus on food additives distracts from more pressing issues like obesity.Experts are being sidelined in favor of political agendas.Public trust in health recommendations has eroded post-COVID.Nutrition policies need to be based on solid scientific evidence.The food industry needs clearer guidance on reformulating products.Future nutrition policies must prioritize public health over political gainRead Dr. Kevin's paperFollow Dr. Kevin on instagramJoin Dr. Spencer's clinic Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Click to read Joy PrescriptionsDrs. Karl and Spencer talk to Dr. Tiffany Moon all about Joy Prescriptions. Learn how to stop chasing perfection and embrace connection. 00:00Introduction to Dr. Tiffany Moon02:02Journey to Reality TV: The Real Housewives of Dallas05:58Life After Reality TV: Finding Joy and Purpose09:59The Joy Prescription: A New Approach to Life17:01Work-Life Integration: Balancing Career and Family22:09Empowering Women: The Lead Her Summit22:33Tiffany's Journey: From Childhood to Medical Success24:43The Quest for Joy: Breaking the Hedonic Treadmill26:42Finding Gratitude and Connection in Life28:37Coping Mechanisms: Humor and Self-Reflection29:57The Joy Prescription: A Path for High Achievers32:29Reconstructing Identity: Beyond External Validation35:37The Impact of Sports on Identity and Achievement40:54Closing Thoughts: Embracing Joy and Connection Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Tirzepatide is more effective for weight loss than semaglutide.Cost-effectiveness is crucial in prescribing weight loss medications.Patients with severe obesity should receive more expensive medications for better outcomes.Both medications show significant benefits for obesity-related conditions.Long-term studies indicate sustained weight loss with both drugs.Gender differences affect weight loss outcomes with these medications.Safety profiles show tirzepatide may be better tolerated than semaglutide.The need for affordable drug pricing is emphasized.Clinical benefits extend beyond weight loss to include metabolic health.Future studies are needed to confirm cardiovascular benefits of tirzepatide.Click here to see the studyClick here to join Dr. Spencer's new online clinic Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

TakeawaysMASH is a significant obesity-related complication.Semaglutide shows promise in treating MASH.Weight loss is crucial for improving liver health.Bariatric surgery remains the most effective treatment.The Essence trial indicates a 63% resolution of NASH.New medications are being developed for obesity treatment.Early intervention is key to preventing severe liver damage.Accessibility of medications is a major concern.Comparative studies are essential for evaluating new treatments.Future treatments may include innovative delivery methods.Chapters00:00 Introduction to MASH and Semaglutide Study04:29 Understanding Metabolic Dysfunction and Its Implications08:02 Essence Trial: Semaglutide's Impact on MASH12:58 Comparative Analysis of New Treatments for MASH17:30 The Future of Obesity Treatment and Drug AccessibilityJoin Vineyard - Dr. Spencer's online clinicSee the study Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with return guest Dr. Lauren Semple about creatine, protein, cortisol, fasting exercise, and training in women.Follow Dr. Lauren's instagramJoin Dr. Spencer's online clinic Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss a new study looking at tirzepatide and metabolic rate. They also discuss a patient case of tirzepatide induced anhedonia.Here is the tirzepatide studyIf interested in joining Dr. Spencer's clinic Vineyard - Click Here  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the claim that GLP-1 meds cause more fat cells.Learn about if and how GLP-1 meds increase fat cells and what that means along with other claims about these medicine.Join Dr. Spencer's online clinic that specializes in GLP-1 medicines Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer talk to Dr. Kenneth Qiu all about direct medical care - the future of medicine.Learn about how bypassing insurance and creating a relationship directly with a doctor can improve your health and save money in the long run.Follow Dr. Qiu on Linked inSee Dr. Spencer's direct care model with Vineyard Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss with Dr. Grant Tinsley all about the new analysis of how much "lean mass" is lost with tirzepatide, the most powerful medicine available for weight loss.Learn:The difference between fat free mass and lean mass and lean soft tissue and muscle.If GLP-1 medicines cause muscle loss specificallyHow to minimize muscle loss when taking these medicinesOur new study together.Click here for the tirzepatide paperClick here to see Dr. Grant Tinsely's InstagramClick here to join Vineyard Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss how bad the Hims and Hers ad was.From an outside perspective, the ad may have seemed good.But when you dig deeper, it was actually really bad.Listen to learn.Join Dr. Spencer's new online clinic - Vineyard. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with NMN and NAD expert Dr. Charles Brenner all about these supposed longevity supplements.Learn about NAD metabolismWhether it's worth supplementing or not with NAD or NMNFollow Dr. Brenner on Twitter Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Fatima Cody Stanford all about obesity, genetics, and her appearance on 60 minutes.Does Dr. Sanford believe lifestyle doesn't matter for obesity?Find out by listening!Watch Dr. Stanford's 60 minute clip Join Dr. Spencer's Obesity Clinic Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat about the new Lancet Commission's report on Clinical Obesity along with the new study on high dosed Wegovy. Learn:How 7.2 mg of Wegovy (semaglutide) compares to 2.4 mgWhat the proposed definitions of clinical and preclinical obesity areClick here to join Dr. Spencer's new online clinic Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Sowa about her book The Ozempic Revolution.Learn:Why she wrote the book.The top 3 things to know when starting a GLP-1 medicine.Also hear the top criticism from Drs. Karl and Spencer. You will laugh.Click here to get the bookIf you're on a GLP-1 currently and want to switch to Dr. Spencer's new clinic, Click Here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the concept of "microdosing" GLP-1 receptor agonists along with talk about the new top line results from REDEFINE which studied the new drug CagriSema.  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Lauren Colenso-Semple all about how the menstrual cycle and how it should affect your workout programming. Should you change your workouts around your menstrual cycle? Find out by listening! Check out her instagramRead her paper on exercise and menstrual cyclesRead her paper on protein synthesis throughout the menstrual cycle Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the topline results from Surmount 5 which put Zepbound (tirzepatide) against Wegovy (semaglutide) for weight loss. They also discuss some news around compounded GLP-1s.Learn:Weight loss and glycemic differences between tirzepatide and semaglutideWhat the FDA is thinking for compounded GLP-1sIf you're not on Dr. Spencer's virtual clinic waitlist, click here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Shivani Misra, a metabolic specialist physician researcher from the UK, all about the various forms of diabetes mellitus.Learn:The types of diabetes mellitusThe monogenic forms (some what refer to as MODY)The differences within type 2 diabetesWhether CGMs (continuous glucose monitors) are usefulIf low carb could help someFollow Dr. Misra on X/Twitter  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with AtlasMD - Dr. Josh Umbehr all about making healthcare cheaper using direct primary care.Learn:How cheap labs and and meds should beHow cutting out the middlemen can help healthcare and decrease costsFind AtlasMD here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the brand new 3 year study of tirzepatide in those with prediabetes along with a discussion on semaglutide treating osteoarthritis.Learn:If people lose weight and keep it off with tirzepatideHow many people regain weight after stopping the medicineLong-term side effectsIf semaglutide helps with osteoarthritisClick here to read the tirzepatide studyClick here to read the semaglutide study Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer invite Dr. Andrea Love back to the podcast to discuss a recent Joe Rogan podcast with Calley and Casey Means along with the concept of Make America Healthy Again and RFK jr.Learn:What the docs agree with.What they don't agree with.Is raw milk okay?Are cancer rates rising?and moreFollow Dr. Andrea here https://www.instagram.com/dr.andrealove Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss all things cortisol and poke fun at the influencers who try to fear monger exercise due to cortisol increases.Learn:What is cortisol and what does it do?Is  cortisol bad?Should you worry about cortisol increases with exercise?Should you take supplements to lower cortisol?and more Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss their ideal healthcare delivery system.Learn:Spencer's journey building and selling Sequence and what he wants to do next.How Dr. Karl believes healthcare should be and what he's doing next.Click here to get on Dr. Spencer's waitlist  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss BS supplements claiming to be like Ozempic along with discuss some new obesity drugs coming down the pipeline that were announced in phase 1 and 2 trials.Are there any supplements that can mimic Ozempic?What is amylin and how does it help with weight and sugars?What is this new oral drug "amycretin" in phase 1 trials?and more Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Jen Gunter all about menopause.Learn:How it's diagnosed.When and when not to treat.The various treatment.If it is indicated for cardiovascular disease prevention or body composition.Whether or not you should get labs.See more at Dr. Gunter's website  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer talk about the top line results from study showing liraglutide may have some benefit in Alzheimer's along with top line results from the Summit trial showing heart failure benefits with tirzepatide.They also discuss the women's boxing controversy and BMI in athletes. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with return guest and bone expert endocrinologist Dr. Rachel Pessah-Pollack all about the new Vitamin D guidelines.Should healthy people even check a vitamin D level?Should they supplement with vitamin D?What people should check or supplement?Click here for the new guidelines  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Does semaglutide cause blindness?What is NAION (nonarteritic anterio ischemic optic neuropathy)?What about worsening of diabetic retinopathy with semaglutide?What can you do to minimize the risk of NAION and retinopathy?Get the full study hereRead Dr. Brugger's blog Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Tirzepatide may be a good option if you have obesity and obstructive sleep apnea.Click here to read the study Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Click here to read about the gastric ablation and trial.Click here to see Dr. McGowan's clinic Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the recent FLOW trial where semaglutide was found to be kidney protective. They also go off about the costs of these medicines and what to do (including compounding considerations). Click here to see the study Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the most recent South Park episode where GLP-1 medicines are discussed along with the dysfunctions of our healthcare system among other issues. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the fallacies of functional medicine. You'll learn what functional medicine is and whether you should seek it out. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer respond to Jillian Michaels on the Bill Maher show Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss with gastroenterologist Dr. McGowan all about endoscopic gastroplasty. See recent study on cost effectiveness of endoscopic gastroplasty vs semaglutide Check out his program Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the new studies about GLP-1 medicines and Parkinson's and heart failure along with how these meds are not just weight loss drugs but health promoting medicines. Click here to see the Parkinson's study Click here to see the heart failure study Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Kasey Potts all about her journey with lipedema. Learn more about how this condition is diagnosed and treated. Check out her instagram Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Amron all about lipedema. He is a specialized surgeon who treats lipedema daily. Learn about diagnosing and treating this condition that is commonly mistaken with obesity. Check his sites https://www.dramronconsultations.com/ https://www.advancedlipedematreatment.com/ Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss a new study showcasing the importance of exercise during and after GLP-1 medicine use. Click here to see the original study Click here to see the extension study Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss a recent Mark Hyman podcast where he perpetuated some myths about obesity and GLP-1 receptor agonist medicines. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss whether your doctor needs to look a certain way in order to be a good doctor. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Drs. Jess and Andrea all about popular podcasters like Andrew Huberman etc. and the spread of pseudoscience. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat about their now defunct supplement company along with the ethics of big pharma direct to consumer marketing (including influencers). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Brianna Durand all about the pelvic floor and incontinence when lifting etc. empower.physio pelvicrehab.org Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Stuart Phillips all about protein. How much do you need to eat for optimal health and body composition and more! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Nicola Guess all about the evidence behind using continuous glucose monitors in those without type 2 diabetes. Learn whether they are useful for even harmful Read her review paper here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the new SELECT results that show a decrease in cardiovascular events in those taking Wegovy who have a history of cardiovascular disease. See trial below https://www.nejm.org/doi/full/10.1056/NEJMoa2307563 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss how tirzepatide is now approved for obesity. Learn: When will it be available How much will is cost Any differences compared to Mounjaro Surmount 3 trial Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Kathleen Keller and Yash Adroja all about brain signaling in kids in relation to obesity. Learn all about Dr. Keller's research that sheds light on taste preferences and food choices made by kids. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat about some of the new tirzepatide studies including SURMOUNT-4 from the EASD Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss with Dr. Bassin all about her review on exercise and physical activity for type 2 diabetes. Check out her review article Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss how semaglutide impacts the heart with new trial data available. Learn how semaglutide may reduce risks of heart attacks and also how it impacts your quality of life if you have heart failure. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Andrea Love all about the microbiome. Find out if it really matters and if there are things to improve it. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Amy Goekel about her history of her eating disorder. Amy has her own podcast where she discusses it is more depth as well https://podcasts.apple.com/us/podcast/the-eating-disorder-diaries/id1666122772 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Andrea Love, a cancer immunologist, about the recent headlines about the WHO listing aspartame as a possible carcinogen. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Pearl all about internalized bias and her recent study on it Click here to read the study Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Jesse Richards all about BBS (Bardet Biedl Syndrome), an unknown cause of genetic obesity. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer sit with Dr. Nagra to discuss the recent WHO news headlines about artificial sweeteners. Find out why you should still drink diet soda instead of regular soda. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss with cardiologist Dr. Luke Laffin about his recent study looking at statins versus various supplements touted as cholesterol-lowering. We also discuss the claim about saunas being better than drugs at lowering mortality. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Angela Fitch, the president of the Obesity Medicine Association and a fellow doc who lifts! They discuss Dr. Fitch's journey into lifting along with the importance of body composition in obesity management. Dr. Fitch is also the CMO of her new company KnownWell. Need an online workout program? Check out LiftRx Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer bring back Dr. Grant Tinsley, a body composition researcher, to go over the GLP-1 data (semaglutide and tirzepatide) in terms of lean body mass loss. Learn:- How much lean body mass is lost in these trials- How body composition is measured- How is muscle loss assessed- Should you be worried if you're taking a GLP-1 agonist Read Dr. Tinsley's blog Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss whether we should call lifestyle measures "medicine". Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the drugs that help you pee out calories - SGLT2 inhibitors. Learn how this type 2 diabetes medicine has turned into a great drug for other conditions. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer go over the common myths of the GLP-1 agonists. Is Ozempic face real? Do people get pancreatic cancer or pancreatitis? Find out by listening! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Leslie Golden about the troubles with insurance covering obesity medicine. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer sit down with Dr. Nicola Guess, an RD PhD scientist, to discuss the new alarming study regarding erythritol. Read the review that goes over the endogenous vs exogenous erythritol Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the worry surrounding lean mass loss while using GLP-1 agonists. Learn: - The usual amount of lean mass loss during weight loss - How much was lost in small subset using semaglutide and tirzepatide - What is the clinical relevance - and more! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the phenomena of those who believe cholesterol (and lipoproteins that carry cholesterol) doesn't cause heart disease. Learn: - How Dr. Spencer was also a skeptic when first starting medical school - How the data are pretty overwhelming for cholesterol/apoB/LDL particles causing heart disease Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer talk with fellow Docs Who Lift and the team of Barbell Medicine Drs. Jordan Feigenbaum and Austin Baraki about the harms of the various hormone clinics out there along with ordering large batteries of tests. Hear Dr. Austin's case study where a huge number of tests were ordered only to give the patient thousands of dollars of supplements and drugs they didn't even need. And get this... they didn't even address the one issue they were having. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Dr. Zeena Al-Rufaie, a pediatric obesity specialist, about the new pediatric obesity guidelines. She gives her own experience as a mother and also a pediatrician about the new guidelines that caused media headlines to spin out of control. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the recent 60 minutes interview where genetics were said to be the number 1 cause of obesity. Learn: - about the outrage that ensued - how the environment and genetics cause obesity together - why some don't get obesity despite the environment - why some need tools to fight back If needing medical tools to fight back, work with Dr. Spencer's group online. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with Abby Langer and Amanda Thebe all about the various red flags you see with quacks online. What are the top nutrition red flags? What about those preying on women going through menopause? and more! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the new pediatric obesity guidelines that have caused an uproar in the media. Are they really pushing drugs and surgery before lifestyle? Find out! Click here to read the actual guidelines Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss a tweet from Steve Crowder. Learn more about judging health by looks (and obesity) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss with Dr. Guillermo Escalante all about the harmful effects of anabolic steroids. Dr. Escalante published a study on autopsies done on bodybuilders who died young. Learn: How anabolic steroids affect the heart Whether there are intrinsic factors beyond blood pressure and lipids Dr. Spencer's patients who use steroids and how he tries to keep them as healthy as possible Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss diet zealots and evangelicals. Learn: What to look out for this New Year so you don't get duped into another diet cult Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss how home body fat scales work and Dr. Tinsley's newest study on their accuracy. Learn: How various methods measure body composition The various compartments How bioimpedance scales work and what the most accurate at home scales are available See Dr. Tinsley's article all about it here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer continue the conversation with The Farm Babe all about ethical farming etc. Find The Farm Babe on: Instagram and Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss agriculture and farming with The Farm Babe. This is part 1 of a 2 part series Learn about safe farming practices and ethical concerns of raising and eating animals and much more. Follow the farm babe by clicking here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the false dichotomy of believing one needs to only do lifestyle OR take a medicine. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with the Food Science Babe all about food science and fear mongering. Get some insight into: GMOs Food additives and shelf-life of foods Learn more by checking out Food Science Babe's instagram Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss a few things from Obesity Week (the big obesity conference in the United States). Learn about: - Dr. Spencer's debate on resistance versus aerobic training. - Some obesity genetics. - and new therapies being studied for obesity. https://liftrx.com/ Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer chat with trainer Dontae Burks about his experience with training young children all the way up to the elderly. What's the best way to get kids to work out? Should kids even lift weights? and more! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer go over the medicines that treat prediabetes and type 2 diabetes. Learn: - Whether you should even treat prediabetes - If you should do medicine before lifestyle - All about metformin - and of course GLP-1s Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the new trend of Hollywood stars using GLP-1 agonists for vanity weight loss and the new weight loss guidelines for medicine and surgery. JoinSequence.com Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss diabetes. What are the different types? What causes these different types? How can you prevent and treat with lifestyle? Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss with Examine.com director Kamal Patel all about supplements. Which ones should you take? Which ones should you avoid? Are fat burners worthwhile? What about testosterone boosters? Find out in this episode. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss a couple metabolic case studies where weight loss is indicated and helpful. For nutrition coaching go to: https://bigrocksnutrition.com/ Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss with Dr. Kevin Klatt, an RD PhD, on whether or not to even pay attention to media headlines about nutrition science. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer sit down with neurobiologist and obesity researcher Dr. Stephan Guyenet to discuss how the brain is the main organ involved in obesity. Learn: How the brain regulates our body fatness The difference between hunger and cravings Why we eat How the new GLP-1 class of medicines help Visit his blog See if you qualify for the GLP-1 medicines Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss with endocrinologist Dr. Bonnecaze all about male obesity-related secondary hypogonadism (low testosterone). Learn: - How obesity causes low testosterone - What to do about it For workouts click here For nutrition help click here For medical weight loss click here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss with Dr. Pessah-Pollack, an osteoporosis focused endocrinologist, all about osteoporosis. Learn: The risk factors for osteoporosis How to screen for it How prevent it Why you should care Use LiftRx to prevent osteoporosis Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer sit down with bariatric surgeon Dr. Garth Davis to discuss the ins and outs of surgery for weight loss. Learn: The types of surgery Whether it is safe or not How well does it work And whether Garth lifts or not. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Spencer and Karl sit down with Ted Kyle to discuss his recent mentions on the Bill Maher show. We go over Ted's advocacy in obesity and how Bill misrepresented Ted's out-of-context quotes. Visit Ted's website here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss with Hormones Demystified, an endocrinologist, about testing for hypothyroidism. Learn: - The basics of testing - Whether TSH is enough - If you need antibodies - If reverse T3 and free T3 are needed - and more! Get Dr. Spencer's Free Start Here guide - download here See Hormones Demystified blog to learn much more about the thyroid Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the origin story of Hormones Demystified and how people get sucked into pseudoscience quackery. Hormones Demystified is one of the top myth busting blogs out there dedicated to discussing hormones. The person behind the blog is anonymous, but you get an inside scoop right here. This is part 1 of a 2 part series. Click here to check out HormonesDemystified.com Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the newly FDA approved medicine Mounjaro (Tirzepatide) and its effect on sugars and weight. It works similarly to the other GLP-1 meds... but better. Learn: How it works How well it works and if you should look into it. go to joinsequence.com if interested Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer have fellow Doc Who Lifts Dr. Bonnecaze back on the show to discuss hypogonadism (low testosterone) in men. Learn: The signs and symptoms of hypogonadism Whether you should get tested or not How to test properly And why most people do it wrong Go to LiftRx to get Dr. Spencer's monthly workout program. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the most powerful medicines currently available for weight loss - the GLP-1s. Learn: How these medicines work How much weight loss on average to expect from these medicine The possible side effects and how to minimize them Go to JoinSequence.com to see if you're eligible for one Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the weight loss effects of phentermine, Qsymia (phentermine/topiramate), and Contrave (bupropion/naltrexone). Learn: How each of these medicines work. How effective each medicine is. Who shouldn't take these medicines. Go to JoinSequence.com for Dr. Spencer's telemedicine program Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer have guest Dr. Alex Bonnecaze on to discuss Orlistat and Plenity. Learn: - How well these two substances work for weight loss - How they they actually work - Side effects - and whether you should even look into them or not. For Dr. Spencer's online clinic - go to JoinSequence.com Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer go over the indications for taking medicines for weight loss. Dr. Spencer's online clinic -> JoinSequence.com Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss whether your hormones are stopping you from weight loss. Learn: Secondary hormonal causes of obesity Is it your thyroid? Cushing's (or other high cortisol causes) Is it all calories in versus out? and more Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer aren't actual vegans, but they did a vegan stint for a month. Take a listen to hear what happened. Learn: What happened to their strength, lipids, and body composition. How Dr. Spencer almost puked from vegan "junk food". Whether or not you can be healthy eating meat. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss weight stigma What is weight stigma? Why is it harmful? What to do about it (it's hard) Consensus statement - https://www.nature.com/articles/s41591-020-0803-x Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Some people say everyone needs a continuous glucose monitor (CGM). Some people say that no one needs one. Drs. Karl and Spencer and joined by two other endocrinologists and two other diabetes educators to discuss: What are CGMs? Do they help in type 1 or 2 diabetes or even prediabetes? What about those without blood sugar issues? Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss incorporating a gym into a doctor's office to utilize exercise as medicine. You'll learn: How this idea came about How it would work Why it is important How Dr. Spencer got fired - LOL only half kidding. Click here to read the published article Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer Nadolsky discuss screening for and treating nonalcoholic fatty liver disease (NAFLD). Learn: - What NAFLD is - Why you should be aware of it - The difference between nonalcoholic fatty liver and nonalcoholic steatohepatitis - What to do if you get it - What diets are best to treat or prevent it Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer Nadolsky discuss the new study on intermittent fasting from the New England Journal of Medicine. You'll learn: - What types of intermittent fasting methods are out there - If they help you lose weight more than just cutting calories in general - If there are other benefits beyond the calorie restriction The NEJM Study Other new study mentioned from the journal Obesity Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss the idea behind metabolically healthy obesity (MHO). Learn: - If it is possible to have obesity and be "healthy" - What entails "health" - How to get healthier Recent review LiftRx.com Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer answer a few questions from a fellow physician. Learn: - How they help their patients with accountability with lifestyle and weight loss - If they prescribe specific diet plans to their patients - and much more www.LiftRx.com Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer go over the common medicines that cause weight gain and some alternatives that can help. Recent meta-analysis from Endocrine Society Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The medical diagnosis of obesity isn't as simple as a BMI anymore. Take a listen to Drs. Karl and Spencer Nadolsky discuss how it should be diagnosed when you walk into a doctor's office. AACE Obesity Guidelines Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss how diet can affect your hypothyroidism. Learn: If you should avoid broccoli or soy If cutting out gluten is worth it If you can even lose weight with thyroid issues Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer discuss in general what they recommend in terms of diet for weight loss. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Karl and Spencer Nadolsky discuss why you're tired and how it is not adrenal fatigue. Learn: - Adrenal gland physiology and pathology - What "adrenal fatigue" allegedly is - Other causes of fatigue - What to do about it Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Drs. Spencer and Karl discuss carbs, insulin, and their role in weight loss and obesity. Recent review on energy balance -> Click Here DIETFITS Study -> Click Here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The Docs Who Lift discuss the impact of artificial (and non-nutritive) sweeteners on weight and glycemia. Read Dr. Karl's peer-reviewed published article on the topic here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The Docs Who Lift discuss the concept of obesity as a disease. Brief overview of the AMA decision to list obesity as a disease. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

A quick intro to the Docs Who Lift. Learn: - Why this podcast was created - Whether exercise is medicine - Who Dr. Spencer and Karl are Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.