From Injections to Pills: Breaking Down the New Oral GLP-1 Data
From Injections to Pills: Breaking Down the New Oral GLP-1 Data  
Podcast: Docs Who Lift
Published On: Thu Oct 23 2025
Description: Show Notes:In this episode of Docs Who Lift, the Nadolsky brothers welcome back Dr. Sean Wharton, clinical trialist and one of the leading researchers behind the next generation of oral GLP-1 medications. Together, they break down:The OASIS-4 trial results on 25mg oral semaglutide and how it stacks up to injectable WegovyHow orforglipron, Eli Lilly’s new small-molecule GLP-1, differs from peptide-based drugsWhy these new therapies could make weight management more accessible and affordableThe fascinating pharmacology behind “snack molecules” and small-molecule receptor agonistsCommon misconceptions about bioavailability, dosing, and side effectsThe potential role of oral GLP-1s for patients with mild obesity or cardiometabolic diseaseWhether you’re a clinician, researcher, or patient curious about the future of obesity medicine, this conversation offers a clear look at how science is shifting toward needle-free solutions.Oasis 1 Trial LinkOasis 4 Trial LinkAttain 1 Trial Link Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.