Podcast:JAMA Clinical Reviews Published On: Mon Jun 16 2025 Description: Adrenal insufficiency is a syndrome of cortisol deficiency. A recent JAMA Review summarizes the pathophysiology, diagnosis, and treatment of adrenal insufficiency and adrenal crisis. JAMA Associate Editor David Simel, MD, MHS, discusses this and more with author Anand Vaidya, MD, MMSc. Related Content: Adrenal Insufficiency in Adults