Peptide of the Week: Retatrutide (GLP-3) – Fat Loss, Brain Boost & Total Control
Peptide of the Week: Retatrutide (GLP-3) – Fat Loss, Brain Boost & Total Control  
Podcast: Peptide of The Week
Published On: Tue Jan 13 2026
Description: Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas return with the first full drop of 2026 and it's a fan-favorite: Retatrutide. Also known as GLP-3, this triple agonist is quickly becoming the most powerful fat loss compound in the peptide world.Whether you're just getting started or you're a seasoned gym rat trying to chisel that last layer of fat, this episode explains exactly why Retatrutide is dominating and how to use it strategically.We cover:🔥 Retatrutide (GLP-3) Breakdown– Triple action: GLP-1, GIP, and Glucagon receptor agonist– Suppresses appetite, increases insulin sensitivity, and boosts metabolic rate– Torches visceral fat, especially in the midsection– Major brain and focus benefits no more “hanger,” no mental fog– Minimal to no nausea compared to semaglutide or tirzepatide– Adaptable for both weight loss and lean bulking it’s all about dosage⚙️ Real Dosing Strategies for Different Goals– JD’s experience: 0.5mg 3x/week got him ultra-lean in just 2 weeks– Beginners: Start at 1mg 3x/week and assess after 2 weeks– Fat loss protocols: ramp up slowly to 5–6mg/week max– Lean bulk protocol: pair with MK-677 or CJC/Ipamorelin for nutrient partitioning💊 Stacking for ResultsFor Fat Loss:– Retatrutide + Tesamorelin (for visceral fat)– + 5-Amino 1MQ (fat cell breakdown)– + L-Carnitine (fuel fat over sugar)– + Sloof (exercise mimetic)For Lean Bulking:– Retatrutide + MK-677 (hunger + growth hormone boost)– + IGF-1 LR3 (nutrient partitioning and local muscle growth)– + Testosterone (non-negotiable for serious gains)⚖️ Why Retatrutide Works for Nearly Everyone– Gym rats = get chiseled without extreme dieting– High-fat dieters = see double the burn from keto-style eating– Busy parents & business pros = regain control of food, energy, and cravings– Women should use extreme caution — not recommended for low-BMI users🧠 Mindset Matters– Retatrutide isn’t a shortcut it’s a tool to help retrain habits– Discipline is a muscle: cutting sugar, eating clean, and saying NO becomes easier– From JD’s carnivore hacks to Will’s own transformation this peptide builds more than bodies📌 Final Recap:– Retatrutide is a scientific breakthrough for fat loss, metabolism, and clarity– It burns fat like butter, kills cravings without killing your appetite, and protects your muscle– Get your blood work, understand your dose, and build the stack that fits your goals💬 Got questions? Drop them in the comments stacks, doses, use cases, we’ll answer them all in the next Q&A.📺 Subscribe now — Q&A episode drops Thursday and we’re just getting started for 2026.