Peptide of the Week: Tesofensine & Methylene Blue – Mood, Focus & Appetite Control
Peptide of the Week: Tesofensine & Methylene Blue – Mood, Focus & Appetite Control  
Podcast: Peptide of The Week
Published On: Mon Dec 15 2025
Description: Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas explore two powerful compounds that aren’t technically peptides but absolutely belong in the conversation for cognitive enhancement, mood regulation, appetite control, and metabolic support.Whether you’re struggling with cravings, brain fog, or just looking to feel sharper and more in control as you head into 2026 this episode breaks it all down with real-world experience and science-backed discussion.We cover:🧠 Tesofensine The dopamine-driven mood & motivation booster– Triple monoamine reuptake inhibitor (serotonin, dopamine, norepinephrine)– Designed to elevate mood, focus, and contentment without artificial spikes– Powerfully reduces cravings by making the brain feel “satiated”– Used off-label as an antidepressant alternative and appetite suppressant– Known to enhance decision-making and reduce impulsive behaviors⚠️ May not be for everyone JD shares his experience of feeling foggy and unmotivated, while Will thrives on it daily🧪 Methylene Blue The mitochondrial optimizer– Originally developed as a medical dye, now used for brain and blood health– Enhances oxygen transport and mitochondrial efficiency– Boosts NAD and glutathione levels for detox, brain clarity, and energy– Shown to help stabilize emotions, mood, and neuroinflammation– May support cognitive function, memory retention, and aging brain cells💡 Best taken on its own do not stack with Tesofensine or SSRIs due to serotonin overload risk👀 Real Talk:– JD and Will explain the massive differences in personal reactions to both compounds– Why you should treat your body as a science experiment: test, track, and pivot– The surprising link between sugar cravings and reduced sex drive– Why Tesofensine may be a better entry point than GLP-1s for appetite control💊 Dosing Recap:– Tesofensine: Start at 250mcg daily, titrate up to 500–1000mcg if well tolerated– Methylene Blue: Use solo, preferably after cycling off other mood regulators📌 Whether you’re trying to reduce nighttime cravings, sharpen your brain, or protect long-term mental health this duo offers next-gen tools for performance and well-being.💬 Got questions or want us to break down other non-peptide cognitive stacks? Drop a comment below.📺 Subscribe for more deep dives no fluff, just real-world feedback.