Dr. David Perlmutter on Menopause, Metabolism & Protecting Your Brain
Dr. David Perlmutter on Menopause, Metabolism & Protecting Your Brain  
Podcast: Live Like a Girl with Dr. Mindy Pelz
Published On: Mon Aug 24 2026
Description: Women are far more likely than men to develop Alzheimer’s disease, and Dr. David Perlmutter believes one of the most important pieces of that story is metabolic health.In this episode of Live Like a Girl, Dr. Perlmutter joins Dr. Mindy to explain what happens when the brain’s immune cells shift from protective to destructive, why menopause may increase vulnerability, and how blood sugar, insulin resistance, visceral fat, inflammation, mitochondrial health, and lifestyle all influence brain aging.They also discuss HRT, GLP-1 medications, ketones, fasting, fiber, exercise, BNDF, sleep, and what women can begin doing in their 30s, 40s, and 50s to support long-term cognitive health.In This Episode, You’ll LearnWhy women face a higher risk of Alzheimer’sHow menopause may affect brain metabolismWhy belly fat and insulin resistance matter for brain healthThe blood markers Dr. Perlmutter watches most closelyWhat emerging research says about GLP-1 drugs and the brainThe lifestyle habits Dr. Perlmutter prioritizes for preventionResources MentionedBrain DefendersTanzi StudyCochrane ReviewMore on Dr. David Perlmutterhttps://drperlmutter.com/http://braindefenders.com/https://www.instagram.com/davidperlmutter/https://www.youtube.com/user/DavidPerlmutterMDhttps://x.com/davidperlmutterlinkedin.com/in/david-perlmutter-mdFor more resources related to today’s episode, visit the podcast episode page: https://www.drmindypelz.com/ep363/Connect with Dr. Mindy:Join Reset AcademyWatch the episodes on YouTubeFollow Dr. Mindy on InstagramSubscribe to Dr. Mindy’s newsletterDisclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle.