AIP for IBD: The Gene Expression Study & Patient Experience Survey (Ep 063)
AIP for IBD: The Gene Expression Study & Patient Experience Survey (Ep 063)  
Podcast: The Autoimmune Wellness Podcast
Published On: Mon Feb 16 2026
Description: Episode 63: AIP for IBD — The Gene Expression Study & Patient Experience SurveyWhat happens inside the body when someone follows the Autoimmune Protocol—and how does AIP actually feel to people using it in real life?In this episode of the Autoimmune Wellness Podcast, Mickey Trescott reviews two important follow-up studies from the Scripps research team, led by Dr. Gauree Konijeti, that expand our understanding of AIP for inflammatory bowel disease beyond symptom improvement alone.The first study examined gene expression changes in intestinal tissue after an AIP intervention in ulcerative colitis. The second explored real-world patient experiences using AIP for Crohn’s disease and ulcerative colitis through a large survey. Together, these studies shed light on both the biological shifts and the lived experience of AIP for IBD.In this episode, you’ll learn:Why researchers examined gene expression changes after AIPWhat the RNA substudy revealed about immune and healing pathwaysWhy these findings matter despite a small sample sizeHow people with IBD experience AIP outside of clinical trialsCommon patterns in symptom improvement and medication useHow personalization and reintroduction typically unfold in real lifeWhat these studies add to the growing AIP research landscapeResources:Scripps RNA Gene Expression Study (2019): An Integrative Clinical Pilot Study to Evaluate RNA Expression Changes in Inflammatory Bowel Disease Following the Autoimmune Protocol DietAIP IBD Patient Experience Survey (2021): Experience Using the Autoimmune Protocol Diet in Inflammatory Bowel Disease: A Patient Survey AIP Foundation Series – Free 5-day email course with printable guides, meal plans, and beginner resources.The New Autoimmune Protocol (Book) – Updated research, Core and Modified AIP guidance, and step-by-step meal plans (available for pre-order).Episode Timeline:00:00 – Introduction: looking beyond symptoms02:23 – Overview of the RNA and patient experience studies03:42 – RNA substudy participant profile06:51 – The AIP intervention used in the RNA analysis07:41 – Clinical outcomes observed in the RNA subgroup10:32 – How RNA gene expression was analyzed13:07 – Results: gene expression and immune pathways16:47 – Introducing the IBD patient experience survey20:21 – Survey results: symptom changes and medication use24:00 – Survey results: food reintroductions28:08 – Recap: what these studies add to AIP research