343: Nucleotides to the Defense
343: Nucleotides to the Defense  
Podcast: This Week in Microbiology
Published On: Sat Oct 25 2025
Description: TWiM explores two different ways that bacteria defend against phages through the synthesis of cyclic nucleotides. Hosts:  Michael Schmidt and Mark O. Martin   Become a patron of TWiM. Links for this episode: Decoy cyclic nucleotides in phage defense (Nature) CRISPR defense with nucleotides (Nature) A decoy defence molecule to set a trap for viruses (Nature) Cyclic oligonucleotide-based antiphage signaling system immunity (Curr Opin Immunol)   Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv