49ERS SQUAD SHOW: Jaguars Pounce on 49ers MULTIPLE TURNOVERS in First Loss of 2025
49ERS SQUAD SHOW: Jaguars Pounce on 49ers MULTIPLE TURNOVERS in First Loss of 2025  
Podcast: Locked On 49ers - Daily Podcast On The San Francisco 49ers
Published On: Mon Sep 29 2025
Description: The San Francisco 49ers did not take care of the football today as they turned it over four times in the 26-21 loss to the Jacksonville Jaguars. Brock Purdy tossed two picks and also fumbled once, while Luke Farrell coughed it up once as well. Christian McCaffrey and the rest of the run game are still searching for that first breakout game this season, as they averaged just 3.5 yards per carry collectively. The San Francisco 49ers will look to rebound quickly as they play the Los Angeles Rams on Thursday. Support Us By Supporting Our Sponsors!5-Hour ENERGYEnough with boring, flavorless caffeine, it’s time to give your caffeine a flavor upgrade with 5-hour ENERGY®️ shots. Get the favorites you love or be bold and try something new in-store and online at https://www.5hourENERGY.com or Amazon today.PelotonLet yourself run, lift, flex, and push forward. Explore the new Peloton Cross Training Tread+ today at https://www.onepeloton.com.RugietReady to level up your confidence in the bedroom? Head to https://www.rugiet.com and use promo code LOCKEDONNFL for 15% off your first order. Monarch MoneyTake control of your finances with Monarch Money. Use code LOCKEDONNFL at https://monarchmoney.com/lockedonnfl for 50% off your first year. SquareTo learn more, go support your favorite neighborhood spot and see what Square has been up to in your neck of the woods. And then if you have extra time, check out https://square.com/go/lockedonnfl.PrizePicksDownload the PrizePicks app today and use code LOCKEDONNFL to get $50 in lineups after you play your first $5 lineup. GametimeDownload the Gametime app, create an account, and use code LOCKEDONNFL for $20 off your first purchase. Terms apply. Download Gametime today. What time is it? Gametime.FanDuelRight now, new customers can bet just FIVE dollars and if your bet wins—you’ll get THREE HUNDRED dollars in bonus bets to use across the app.FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.