FAMILIAR FOES: 49ers Visit Texans and Old Friend DeMeco Ryans in Defensive Battle
FAMILIAR FOES: 49ers Visit Texans and Old Friend DeMeco Ryans in Defensive Battle  
Podcast: Locked On 49ers - Daily Podcast On The San Francisco 49ers
Published On: Thu Oct 23 2025
Description: Can the Houston Texans' stifling defense slow down the San Francisco 49ers' high-powered offense? This clash of strengths takes center stage as the teams prepare for a crucial matchup. John Hickman and Brian Peacock break down the key factors that could decide the game. They analyze the 49ers' ability to overcome injuries, the Texans' impressive run defense, and the impact of Mac Jones filling in for Brock Purdy. The hosts also examine C.J. Stroud's challenges behind a struggling offensive line and offer their predictions for what could be a low-scoring affair. San Francisco 49ers fans are treated to daily news and analysis with Locked On 49ers, hosted by football analyst Brian Peacock and former NFL/AFL cornerback Eric Crocker. Follow & Subscribe on all Podcast platforms…🎧 https://link.chtbl.com/LO49ers?sid=YouTube Locked On NFL League-Wide: Every Team, Fantasy, Draft & More🎧 https://linktr.ee/LockedOnNFL Follow Brian Peacock and Eric Crocker on Twitter, where they’ll be sharing the latest news about the Niners and talking with fans.Twitter: twitter.com/BDPeacock, twitter.com/eric_crocker Support Us By Supporting Our Sponsors! PelotonLet yourself run, lift, flex, and push forward. Explore the new Peloton Cross Training Tread+ today at https://www.onepeloton.com. RipplingGet Rippling FREE for 6 months. Terms and conditions apply. See site for details: https://app.rippling.com/legal/promoterms PrizePicksDownload the PrizePicks app today and use code LOCKEDONNFL to get $50 in lineups after you play your first $5 lineup.Click Here: https://prizepicks.onelink.me/LME0/LOCKEDONNFL GametimeDownload the Gametime app, create an account, and use code LOCKEDONNFL for $20 off your first purchase. Terms apply. Download Gametime today. What time is it? Gametime. FanDuelRight now, new customers can bet just FIVE dollars and if your bet wins—you’ll get THREE HUNDRED dollars in bonus bets to use across the app. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.