Harvard Doctor reveals #1 Cause of Aging You've Never Heard Of | Dr. Andrew Salzman
Harvard Doctor reveals #1 Cause of Aging You've Never Heard Of | Dr. Andrew Salzman  
Podcast: The Dr. Josh Axe Show
Published On: Thu Jun 25 2026
Description: What if aging isn’t simply your body “wearing out”… but your body losing the ability to repair itself? In this episode, Dr. Andrew Salzman joins Dr. Josh Axe to explain why chronic inflammation, leaky gut, and depleted NAD may quietly drain the very energy your cells need to heal, think, move, and survive. Uncover what’s really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! →  http://mybloodwork.com Thank you to our sponsors! Sunlighten Sauna: https://get.sunlighten.com/axepodcast Manukora Manuka Honey: https://manukora.com/axe Caraway Home: carawayhome.com/drjoshaxe (Use code DRJOSHAXE) for an exclusive discount Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1 🎧 Early Access! Our listeners enjoy every episode before anyone else! Tune in below and join our exclusive group of listeners →  Spotify: https://bit.ly/DrJoshAxeSpotify Apple Podcast: https://apple.co/3JDvWcS Pre-order my NEW BOOK, Heal Your Cells → https://bit.ly/3QJBcQ5 Watch my free training on how to naturally balance your blood sugar and reverse your symptoms → http://DrAxeDiabetesClass.com Discover practical steps you can take today to start healing your thyroid naturally →   http://DrAxeThyroidClass.com If you’re ready to start feeling like yourself again and balance your hormones, take my free class → http://DrAxeHormoneClass.com CONNECT WITH DR. JOSH AXE Instagram → https://www.instagram.com/drjoshaxe/ Facebook → https://www.facebook.com/DrJoshAxe/ TikTok → https://www.tiktok.com/@thedrjoshaxeshow/ X → https://x.com/drjoshaxe/ LinkedIn → https://www.linkedin.com/in/joshaxe Website →  http://thehealthinstitute.com Sign up for my newsletter → https://bit.ly/4oE9Jf3 Ask Dr. Axe → http://speakpipe.com/drjoshaxe   00:00 — Why Aging Is A Defect In Repair, Not Wear And Tear 01:42 — Meet Dr. Andrew Salzman: Harvard ICU Doctor & NAD Pioneer 03:07 — The 1991 Discovery That Changed Leaky Gut Research 06:59 — Why Doctors Dismissed Leaky Gut For Years 09:46 — DNA Damage, PARP Activation & The NAD Collapse 12:41 — How PARP Inhibitors Stopped Leaky Gut In The Lab 14:35 — What NAD Actually Does Inside Your Cells 21:31 — Best Food Sources For NAD & Creatine Support 24:55 — How Chronic Inflammation Activates PARP 25:56 — CD38: The Enzyme Draining Your NAD With Age 27:10 — NR vs NMN vs Niacin: Which NAD Supplement Makes Sense? 30:02 — Why NAD Is The “Centerpiece Of Biology” 34:24 — The Mouse Study Linking CD38, NAD & Ovarian Aging 35:30 — Why The Brain Is So Vulnerable To Low Cellular Energy 36:57 — Mitochondria As Power Stations: Why ATP Still Needs Delivery 39:31 — Butyrate, Brown Rice & Foods That Help Seal The Gut 41:59 — Flagella, LPS & The Hidden Drivers Of Gut Inflammation 43:36 — Dr. Salzman’s Top Longevity Priorities 45:45 — The New Definition Of Aging: Failed Repair 48:55 — Why Older Bodies Can Be “Operating On Fumes” 51:16 — NAD, Oxygen & Tissue Repair After Major Injury 55:35 — Creatine Dosage, Daily Loss & Why Supplementing May Matter 57:54 — Where To Find Dr. Salzman’s Research 59:01 — Final Thoughts: NAD, Creatine & Cellular Longevity DISCLAIMER This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program. MB01ECARA9TSXF7 Learn more about your ad choices. Visit megaphone.fm/adchoices