Study Deep Dive: Creatine is SAFE
Study Deep Dive: Creatine is SAFE  
Podcast: The Dr. Layne Norton Podcast
Published On: Mon Oct 20 2025
Description: Creatine is SAFE, the verdict is in!After decades of people claiming that creatine will wreck your kidneys, liver, & various other claims, a new study has put these myths to bed. In my latest episode of the Dr. Layne Norton Podcast, I go DEEP on the most comprehensive dataset to date: a brand new meta-analysis by Kreider et al. (2025) which reviewed 250+ studies, covering over 26,000 participants, some lasting more than a decade, and examined nearly 50 potential side effects.The verdict? Absolutely no evidence of harm.I broke down the full paper, the methods, and what this means for athletes and everyday lifters in the latest episode of the podcast.SPONSORS• Outwork Nutrition - Evidence-Based Supplements to Support Your Hard Work: https://outworknutrition.com• REPS Research Review: https://biolayne.com/repsLAYNE'S COMPANIESCarbon Diet Coach: https://joincarbon.com/podcastOutwork Nutrition: https://outworknutrition.comREPS Research Review: https://biolayne.com/repsWorkout Builder: https://biolayne.com/workout-builderTeam Biolayne: https://biolayne.com/online-coachingPhysique Coaching Academy: https://physiquecoachingacademy.comFOLLOW LAYNEhttp://www.facebook.com/laynenortonhttp://www.twitter.com/biolaynehttp://www.instagram.com/biolayneTIMESTAMPS0:00:00 - Intro0:01:33 - Meta Analysis Overview0:02:14 - Creatine is NOT a Steroid0:03:10 - ATP0:05:13 - Creatine from Body and Food0:06:05 - Creatine Non-Responders0:06:27 - Creatine Dose0:07:10 - Creatine Benefits0:10:18 - Outwork Nutrition0:11:46 - Interesting Associations0:13:48 - Safety Questions0:15:03 - Importance of Placebo0:17:05 - Study Methods0:20:05 - Study Results0:26:08 - REPS Research Review0:26:57 - Hair Loss0:29:04 - Creatine is Safe and Effective0:30:54 - Types of Creatine0:36:54 - Creatine for Kids0:38:50 - Recommendations0:39:39 - OutroSHOW NOTEShttps://biolayne.com/podcasts/dr-layne-norton-podcast/study-deep-dive-creatine-is-safe-episode-13