Gene Therapy for Parkinson's: Myths vs. Facts
Gene Therapy for Parkinson's: Myths vs. Facts  
Podcast: The Parkinson's Podcast
Published On: Mon Nov 17 2025
Description: In this episode of the Parkinson's Podcast, learn about gene therapy for Parkinson's, including common misunderstandings and ongoing research about it.  This episode contains some technical terms and abbreviations. For your convenience, here is a short list of definitions that might be helpful.   AADC – Aromatic L-Amino Acid Decarboxylase: An enzyme that helps make dopamine (not a rock and roll band)  AAV – Adeno-Associated Virus: A harmless virus used to deliver gene therapy  CDNF – Cerebral Dopamine Neurotrophic Factor: A protein that helps keep dopamine-producing cells healthy  DBS – Deep Brain Stimulation: A surgical treatment that uses electrical signals to help control symptoms  GAD – Glutamic Acid Decarboxylase: An enzyme that helps rebalance brain circuits.   GBA – A gene linked to Parkinson's risk  GCH1 – GTP Cyclohydrolase 1: An enzyme that supports dopamine production.   GDNF – Glial Cell Line-Derived Neurotrophic Factor: A protein that helps protect brain cells  LRRK2 – A gene linked to Parkinson's risk  PARK2 – A gene linked to Parkinson's risk  PET – Positron Emission Tomography: A brain scan that shows chemical activity   PINK1 – A gene linked to Parkinson's risk   SNCA – A gene linked to Parkinson's risk  More information about Gene Therapy for Parkinson's is available here:  https://davisphinneyfoundation.org/blog/gene-therapy-parkinsons/   https://youtu.be/n2KNtRK3SIk  https://youtu.be/v9mJiO4EEag    Sign up for updates on webinars, events, and resources for the Parkinson's community: https://dpf.org/newsletter-signup