GLP-1: New Metrics, New Molecules, New Prices
GLP-1: New Metrics, New Molecules, New Prices  
Podcast: On The Pen GLP-1 News
Published On: Tue Dec 02 2025
Description: Send a textTopics We Cover:00:00 – New data from Harvard/Mass General may classify nearly 70% of adults as having obesity03:00 – A new oral triple agonist shows record-setting absorption rates07:00 – Fractal Health’s Revita procedure: weight maintenance after stopping GLP-1s12:00 – Zepbound vial prices drop (full breakdown by dose)16:00 – Dave’s personal experience switching off Mounjaro and intense hunger return22:00 – Novo Nordisk’s EVOKE/EVOKE+ Alzheimer’s trial: what the data really means29:00 – Why GLP-1 neurological research is just getting started33:00 – Updates on access, partners, and major news coming soon for Medicare patientsIf you’re on Wegovy, Mounjaro, Zepbound, Saxenda, Trulicity, or compounded versions, this episode gives you the insight and context you need to have more competent and confident conversations with your doctor.Bullet Point Summary of the Podcast EpisodeNew Obesity Measurement Data (Harvard/Mass General Study)Harvard and Mass General propose adding waist circumference to BMI to better diagnose obesity.Traditional BMI misses key factors like muscle mass and body composition.Using the updated measure, Americans classified as obese jumps from ~43% to almost 69%.This means 7 out of 10 U.S. adults would now qualify as having the disease of obesity.Dave notes this validates many people who “feel” metabolically unwell despite a “normal” BMI.Reinforces his claim that “most people should be talking to their doctors about GLP-1s.”New Oral Triple Agonist (Ascletis – ASC41/ASC? Molecule)From Ascletis (A-S-C-L-E-T-I-S), developing an oral triple agonist targeting:GLP-1GIPGlucagonSimilar in mechanism to retatrutide, expected around 2027.Preclinical (animal) data show stunning results:Oral bioavailability of 4.2%9× higher than tirzepatide30× higher than oral semaglutide6× higher than oral retatrutide57× greater drug exposure than oral retatrutideHalf-life ~56 hoursStronger receptor activation than retatrutide in vitroSuggests potential for the first powerful oral triple agonist—worth watching.️ 3. Discussion of the Gray Market / TikTok ExperienceDave briefly recounts losing his TikTok account and landing in an algorithm filled with teenagers promoting gray-market “retatrutide.”Expresses concern over unregulated peptide sales, especially to minors.Fract🤝 Visit Our Sponsors!OTPLinks.com Decoding GLP-1 BookDecoding GLP-1: A Guide for Friends and Family of Those On The PenBuy Here: https://amzn.to/3Dc66d4MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:Venmo: OnThePenCa$h App: ManOnMounjaroBECOME A MEMBER:https://www.youtube.com/channel/UCDocQ-4IhVS3ihy_dW7nSKw/join👉 My Amazon Affiliate Store:https://www.amazon.com/shop/manonthemounjaroonthepenWATCH MORE!📺 We're Live M/W/F at 11 central: onthepen.tv 📲 Contact Me: dave@onthepen.comThank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.