The evolutionary science behind why you can’t lose weight and how to avoid 5 modern food mistakes | Prof Daniel Lieberman
The evolutionary science behind why you can’t lose weight and how to avoid 5 modern food mistakes | Prof Daniel Lieberman  
Podcast: ZOE Science & Nutrition
Published On: Thu Aug 06 2026
Description: Why can’t you lose weight, and why do modern diets fail? Today, Harvard professor Daniel Lieberman explains how evolution shapes hunger, body fat, food cravings, and modern food mistakes. You will learn why eating well can feel so hard in today’s food world. Using themes from Daniel’s new book, Fed Up: What Evolution Reveals about Food, Diet and Eating Well, we explore how our modern food environment explains weight gain, failed diets, and confusion about what to eat. We discuss calorie counting, ultra-processed food, hunger, and why there may be no single “best” diet for everyone. By the end of the episode, you’ll have some simple ways to make better food choices and will know how to make healthy choices easier. If your body evolved for a world where food was scarce, what does that mean for how you eat today? 🌱 Try our science-backed and tasty wholefood supplement Daily30 🌿Let your gut microbes snack on the ZOE Gut Health Bar Build healthy habits. Download the ZOE app today and start your trial for just £2.30 for your first week. 👉 Join ZOE Follow ZOE on Instagram. Timecodes 00:00 Intro 03:34 The 3 reasons evolution changes what you eat 07:28 Why supermarkets make healthy eating harder 10:51 Why sugar and fat are so hard to resist 12:12 Are humans really fatter than hippos? 13:20 Why your brain burns so much energy 14:25 Why humans evolved to hold onto fat 16:06 The 3 hidden costs behind body fat 18:23 How cooking changed the human body 19:15 Why raw food may not be natural for humans 22:08 Did farming make humans less healthy? 24:49 How processed food transformed what we eat 28:22 Why modern food triggers ancient cravings 29:48 What the paleo diet gets wrong 31:08 Why there is no real paleo diet 31:55 Why calorie counting can mislead you 33:05 Why hunger beats willpower 34:20 Why weight loss often comes back 35:56 What you need to know before buying food 36:53 Why no diet is truly optimal 38:24 What the healthiest diets have in common 40:08 Are your genes really making you gain weight? 41:40 The simple shopping trick Daniel uses 43:46 Why the 8-hour sleep rule is wrong 45:25 Why stress makes you crave comfort food 51:30 Why simple diet rules fail 📚Books by our ZOE Scientists The Food For Life Cookbook Every Body Should Know This by Dr Federica Amati The Appetite Reset by Dr Federica Amati Food For Life by Prof. Tim Spector Ferment by Prof. Tim Spector Good Mood Food (preorder) by Prof. Tim Spector Free resources from ZOE The Smart Snacking Guide: How to feed your gut, fuel your day, and snack without guilt The Hormone Harmony Guide: Tuning Your Body’s Internal Orchestra   Eating for Better Brain Health: Your brain-gut blueprint How to eat in 2026 - Discover ZOE’s 8 nutrition principles for long-term health Live Healthier: Top 10 Tips From ZOE Science & Nutrition Gut Guide - For a Healthier Microbiome in Weeks  Better Breakfast Guide Mentioned in today's episode Fed Up: What Evolution Reveals about Food, Diet and Eating Well by Daniel Lieberman Comparing dietary variation between tropical hunter-gatherer groups to the Paleo Diet, The American Journal of Clinical Nutrition (2023) The carbohydrate-insulin model: a physiological perspective on the obesity pandemic, The American Journal of Clinical Nutrition (2021) Have feedback or a topic you'd like us to cover? Let us know here. Episode transcripts are available here.